Beilstein J. Org. Chem.2013,9, 1012–1044, doi:10.3762/bjoc.9.116
relationships with regards to affinity for target and brain kinetics. Several probes discussed herein show particularly promising results and will be of immense value moving forward in the fight against AD.
Keywords: Alzheimer’s disease; in vivo detection; near-infrared fluorescence probes; PET/SPECTimaging
resulted in a variety of radiolabeled molecular probes for in vivo PET/SPECTimaging. The scaffolds from which these newer radiolabeled probes are derived include chalcone (5) and its conformationally restricted analogues flavone (6) and aurone (7); stilbene (8) and its analogues diphenyl-1,2,4-oxadiazole
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Graphical Abstract
Figure 1:
Structures of A. dyes originally used to stain Aβ and B. newer scaffolds explored for the developme...